Scientists from the University of Nottingham report that a substance called tapsigargin is effective in inhibiting the multiplication of all variants of the coronavirus. It is obtained from the Apulian łoczył (Thapsia garganica). The research results were published in the journal “Virulence”.
Researchers from the University of Nottingham have noticed in previous experiments that the substance triggers a strong response in the body against various viruses, including SARS-CoV2, even in small doses.
Meanwhile, in new experiments, they first compared the cellular activity of different variants of the coronavirus – alpha, beta, and gamma. The delta variant multiplied 4 times faster than the alpha variant – and 9 times faster than the beta variant. At the same time, it was most efficient at moving to the next cells. As it turned out, infection with different variants at the same time usually gave a synergistic effect, i.e. the viruses accelerated each other’s replication.
Tapsigargin effectively protects against infection
However, researchers also have good news. In cell studies, all variants of the coronavirus were susceptible to the effects of tapsigargin. The substance effectively protected against infection and inhibited the already existing infection.
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– The study gave us a better insight into the nature of the delta dominance. Although we have shown that it is the most infectious and promotes the production of other viruses in co-infection, we are pleased because we have shown that tapsigargin is effective against all variants, says Prof. Kin Chow Chang.
Together, these results show the antiviral potential of tapsigargin for post-exposure prophylaxis and as a therapeutic substance, he adds.
Apulian łoczydło – where does it grow?
Plants from which Tapsigargin is obtained are found in the Mediterranean basin – in southern Europe, Asia Minor and northern Africa.
The milk juice from the wafer was used in healing in antiquity and the Middle Ages.
dsk / PAP, polsatnews.pl