The use of aspirin is associated with a 26 percent higher dose. risk of heart failure in people with at least one predisposing factor to the disease, according to a study published in ESC Heart Failure, the journal of the European Society of Cardiology (ESC).
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– This is the first study in which it was found that among patients with at least one risk factor for heart failure, recipients aspirin were more likely to develop the disease later than non-users, said study author Dr Blerim Mujaj of the University of Freiburg, Germany. ‘While the results need to be confirmed, they do show that the potential link between aspirin and heart failure needs to be clarified,’ he added.
What are the risks of using the drug for individual people?
The effect of aspirin on heart failure is controversial. A new study looked at the association of this drug with the occurrence of heart failure in people with and without heart disease, and whether its use was associated with new diagnoses of heart failure in people at risk.
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The analysis included 30,827 people from Western Europe and at risk of heart failure USAthat were included in the HOMAGE study. Smoking, obesity, high blood pressure, high cholesterol, diabetes and cardiovascular disease have been considered as factors predisposing to failure.
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Participants were 40 years of age or older and had no heart failure at the start of the study. It was then recorded whether they were taking aspirin or not. The authors monitored whether these people developed heart failure – fatal or non-fatal but requiring hospitalization.
The average age of the participants was 67 and 34 percent. the groups were women. At the beginning, a total of 7,698 respondents (25%) were taking aspirin. During 5.3 years of follow-up, heart failure occurred in 1,330 patients.
Researchers assessed the relationship between aspirin use and incidental heart failure after adjusting for gender, age, body mass index, smoking, alcohol consumption, blood pressure, heart rate, blood cholesterol, creatinine, high blood pressure, diabetes, cardiovascular disease and treatment with inhibitors of the renin-angiotensin-aldosterone system, calcium channel blockers, diuretics, beta-blockers and lipid-lowering drugs. Taking aspirin was independently associated with an increase by 26%. the risk of a new diagnosis of heart failure.
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Consistency of the results
To check the consistency of the results, the researchers repeated the analysis after matching aspirin and non-aspirin users for heart failure risk factors. And in this analysis, aspirin was associated with a 26 percent increased risk of a new diagnosis of heart failure. To check the results further, the analysis was repeated after the exclusion of patients with a history of cardiovascular disease. In 22,690 participants (74%) free from cardiovascular disease, the use of aspirin was associated with a 27% higher dose. risk of developing heart failure.
This was the first large study to investigate the association between the use of aspirin and incidental heart failure in people with and without heart disease and with at least one risk factor. Aspirin is widely used – in our study every fourth respondent took the drug. In this population, the use of aspirin was associated with incidental heart failure, regardless of other risk factors, Dr. Mujaj noted. “You need large international randomized tests in adults at risk of heart failure to verify these results. Until then, our observations suggest that aspirin should be prescribed with caution in people with heart failure or disease risk factors. ”