A striking new partnership is born, as Romelu Lukaku and Paulo Dybala start together for the first time, while Ivan N’Dika makes his Serie A debut as Roma host rock bottom Empoli.
It will kick off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
You can follow this match and all the preparations and activities on the liveblog from Fiorentina-Atalanta.
The Giallorossi had a poor start to the season, drawing 2–2 with Salernitana and then suffering consecutive defeats against Verona and 10-man Milan.
The injury problem continues to grow as Houssem Aouar, Lorenzo Pellegrini and Chris Smalling join Tammy Abraham and Marshawn Kumbula in the stand, but the good news for Jose Mourinho is that Lukaku and Dybala are both set to make their first starts together. Are ready for.
Leandro Paredes and Renato Sanches have also overcome problems, while summer signing N’Dika made his Serie A debut in defence.
Empoli are bottom of the table and have failed to pick up a single point or even score a goal.
Daniel Maldini and goalkeeper Elia Caprile are still out, while Mattia Destro is a surprise centre-forward.
Rome: Rui Patricio; Mancini, Lorente, Nadika; Christensen, Cristante, Paredes, Renato Sanches, Spinazzola; Dybala, Lukaku
Empoli: Berisha; Berezinski, Walukiewicz, Luperto, Pezzella; Maleh, Grassi, Fazzini; Cancellieri, Destro, Cambiaghi