Viagra significantly lowers the risk of developing Alzheimer’s disease

Viagra is a potency tablet, the active substance of which is sildenafil in the form of citrate (belongs to the group of phosphodiesterase inhibitors type 5 – an enzyme found in the corpora cavernosa and pulmonary circulation). Initially, the drug was supposed to serve as a cardiac preparation, because it dilates and tones the blood vessels, which improves blood circulation. Only then was it discovered that it was also effective in treating erectile dysfunction.

Periodically, Viagra is tested for other uses. For example, a few years ago it was discovered that small doses of this drug, taken daily, reduced the risk of developing colorectal cancer. This discovery was reported in 2018 by scientists from Augusta University in the USA. Sildenafil is also used in the treatment of pulmonary hypertension. There have also been studies done on how Viagra works in vascular dementia (vascular dementia).

We learn about other advantages of the drug from studies conducted, among others, by at Cleveland Clinic (USA). Scientists in an article in the journal Nature Aging argue that Viagra is worth investigating for its next use.

– We identified sildenafil as a potential risk modifier of Alzheimer’s disease. Based on a retrospective analysis of data covering a group of 7.23 million people, we found that the use of sildenafil was associated with a 69% reduced risk of developing the disease, the researchers report.

In other words: those who used Viagra regularly had less Alzheimer’s disease. – The relationship between the use of sildenafil and the lower incidence of the disease does not yet establish a causal relationship that will require a randomized controlled trial, however, the researchers reserve.

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What the researchers found

High (higher than recommended) doses of the drug promote the growth of brain cells and reduce the accumulation of tau protein, which is associated with Alzheimer’s disease.

– We found that sildenafil increases the growth of neurites and reduces the expression of hyperphosphorylated tau protein (P-tau) in models of neurons derived from induced pluripotent stem cells obtained from patients with Alzheimer’s disease – report ± researchers.

In addition, analyzes of medical data from the last six years, covering a group of 7.23 million people, have allowed scientists to establish that people taking sildenafil had less Alzheimer’s disease.

The scientists commenting on this finding emphasize that only clinical trials can tell us whether Viagra actually prevents brain disease.

Sources: BBC.com, Nature.com

About Peter Wilson

In love with technology, with an eye towards smartphones, he does not disdain any activity linked to the Nerd world. TV series, movies, manga, anime, and comics (Marvel addicted) are the order of the day.

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